Abstract—The Inter-Carrier-Interference (ICI) is considered a bottleneck in the utilization of Multiple-Input-Multiple-Output Orthogonal Frequency Division Multiplexing (MIMO-OFDM) systems, due to the sensitivity of the OFDM towards frequency offsets that losses the carrier orthogonality and generates signal interference that causes system performance degradation. In this paper Residue Numbers as a coding scheme is impeded in MIMO-OFDM systems, where the ICI levels is measured and evaluated with respect to the conventional ICI mitigation techniques as pulse shaping, windowing and self-cancellation techniques implemented in MIMO-OFDM system. The Carrier-to-Interference Ratio (CIR), the system Bit-Error-Rate (BER) and the Complementary Cumulative Distribution Function (CCDF) for MIMO-OFDM system with Residue Number System (RNS) coding are evaluated. The results demonstrated a performance enhancement of transmission model over the system without RNS implementation.