Abstract—This work analyzes the architectural complexity of a Multi-Layer Perceptron (MLP) Artificial Neural Network (ANN) model suitable for modeling and predicting signal power loss in micro-cellular environments. The MLP neural network model with one, two, and three hidden layers respectively were trained using measurement datasets used as the target values collected from a micro-cell environment that is suitable to describe different propagation paths and conditions. The neural network training has been performed by applying different training techniques to ensure a well-trained network for good generalization and avoid over-fitting during network training. Bayesian regularization algorithm (that updates weights and biases during network training) following the Levenberg-Marquardt optimization training algorithm was used as the training algorithm. A comparative analysis of training results from one, two, and three hidden layers MLP neural networks show the best prediction result of the signal power loss using a neural network with one hidden layer. A complex architectural composition of the MLP neural network involved very high training time and higher prediction errors.